Béatrice Roques

Pharmacocinétique/Pharmacodynamie et modélisation

• Predicted efficacy and tolerance of different dosage regimens of benzylpenicillin in horses based on a pharmacokinetic study with three IM formulations and one IV formulation - Ferran AA, Roques BB, Chapuis L, Kuroda T, Lacroix MZ, Toutain PL, Bousquet-Mélou A, Lallemand EA - Frontiers in Veterinary Science, 2024 DOI: 10.3389/fvets.2024.1409266

• Pharmacokinetic-pharmacodynamic cutoff values for benzylpenicillin in horses to support the establishment of clinical breakpoints for benzylpenicillin antimicrobial susceptibility testing in horses - Lallemand EA, Bousquet-Mélou A, Chapuis L, Davis J, Ferran AA, Kukanich B, Kuroda T, Lacroix MZ, Minamijima Y, Olsén L, Pelligand L, Ramon Portugal F, Roques BB, Santschi EM, Wilson KE, Toutain P-L - Frontiers in Microbiology, 2023 DOI: 10.3389/fmicb.2023.1282949

• Control of a sulfadoxine/trimethoprim combination in the competition horse: elimination, metabolism and detection following an intravenous administration - Schenk I, Broussou D, Roques BB, Lagershausen H, Machnik M, Röttgen H, Toutain P-L, Thevis M - Drug Testing and Analysis, 2023 DOI: 10.1002/dta.3461

• Doxycycline serum protein binding in pigs reveals a relatively high free fraction - Ramon Portugal F, Lacroix MZ, Roques BB, Gayrard V, Toutain P-L, Bousquet-Mélou A - Journal of Veterinary Pharmacology and Therapeutics, 2023 DOI: 10.1111/jvp.13111

• Population pharmacokinetics of intravenous amoxicillin combined with clavulanic acid in healthy and critically ill dogs - Vegas Cómitre MD, Cortellini S, Cherlet M, Devreese M, Roques BB, Bousquet-Mélou A, Toutain P-L, Pelligand L - Frontiers in Veterinary Science, 2021 DOI: 10.3389/fvets.2021.770202

• Prediction of minocycline activity in the gut from a pig preclinical model using pharmacokinetic-pharmacodynamic approach - Vallé Q, Roques BB, Bousquet-Mélou A, Dahlhaus D, Ramon Portugal F, Dupouy V, Bibbal D, Ferran AA - Frontiers in Microbiology, 2021 DOI: 10.3389/fmicb.2021.671376

• Kinetics disposition of diazepam and its metabolites after intravenous administration of diazepam in the horse: relevance for doping control - Schenk I, Machnik M, Broussou D, Meuly A, Roques BB, Lallemand EA, Düe M, Röttgen H, Lagershausen H, Toutain P-L, Thevis M - Journal of Veterinary Pharmacology and Therapeutics, 2021 DOI: 10.1111/jvp.12991

Optimisation des traitements antibiotiques en élevage

• Delivery strategies to improve piglets exposure to oral antibiotics - Hernández N, Roques BB, Lacroix MZ, Concorder D - arXiv preprint, 2024 arXiv:2405.11004

• Determination of optimal ratios for three sulfonamides/trimethoprim combinations against E. coli using checkerboard and time-kill assays - Boulanger M, Tchalaou S, Roques BB, Ferran AA, Viel A - 15th International Congress of the EAVPT, 2023

• Levers to improve antibiotic treatment of lambs via drinking water in sheep fattening houses: the example of the sulfadimethoxine/trimethoprim combination - Ferran AA, Lacroix MZ, Bousquet-Mélou A, Duhil I, Roques BB - Antibiotics, 2020 DOI: 10.3390/antibiotics9090561

• Can oral group medication be improved to reduce antimicrobial use ? - Ferran AA, Roques BB - Veterinary Record, 2019 DOI: 10.1136/vr.l5656

• F2E Carnot PigPills, “Development of an innovative method of oral antibiotic administration to allow automatic individual drug delivery in pig farms”, 2023-2025 (Porteur de projet et leader WP2, co-direction PhD Marine Lacampagne avec Marlène Lacroix)

• JPI-AMR SulTAn, “Optimized dosing regimens for the combinations of sulfonamides and trimethoprim in veterinary medicine”, (Responsable études et analyses pharmacocinétiques chez le bovin, co-direction PhD Marine Boulanger avec Aude Ferran et Alexis Viel)